Promotion of collagen synthesis (in vivo)
Collagen plays important roles in the skin such as keeping skin turgor, and so on. It would be considered that we should take an amino acid mixture as a material for collagen synthesis. However, the study below shows that CTP is more effective than amino acid in ingestion.
Test for promotion of collagen synthesis of the skin [1]
1) Methods
- <Test sample>
- 1. Control group : Purified water
- 2. Gelatin group
- 3. Collagen peptides group
- 4. CTP-containing collagen group
- 5. Amino acid mixture group
- <Measurement method>
- The soluble fractions from dermises of the rats which were administered the above test samples orally and had received treatment according to the method by Nimni et al., [2] were subjected to quantitative measurement by HPLC for hydroxyproline quantity (used as an index of collagen quantity).
2) Results and Discussion
Each hydroxyproline quantity in the soluble fractions from dermises of the rats is shown in the figure below. The result confirmed that the oral ingestion of CTP-containing collagen had higher promotion effect on collagen synthesis of dermis than that of other test samples: undecomposed gelatin, pepsin degradation products and amino acid mixture in collagen. Therefore, it is suggested that the most efficient ingestion form is to take collagen as CTP.
Activating promotion of collagen synthesis in various hydrolyzed collagen products
[1] Fragrance Journal 2003.12
[2] M.E. Nimni et al., Arch. Biochem. Biophys.,122, 292 (1967)
